|
KMID : 1189220070340040285
|
|
Korean Journal of Reproductive Medicine
2007 Volume.34 No. 4 p.285 ~ p.291
|
|
|
Outcome of in vitro Fertilization in Women ≥40 Years of Age
|
|
Kwon Cheo-Jin
Lee Sang-Hee
Kang Eun-Hee
Kim Jong-Sik
Jung Byeong-Jun
|
|
|
Abstract
|
|
|
Objective: To evaluate the outcomes of in vitro fertilization and embryo transfer (IVF-ET) in women over 40 years of age.
Methods: A total of 170 patients (271 cycles) over 40 years of age who underwent IVF-ET at Seoul Women’s Hospital (Incheon, Korea) were analyzed in this study retrospectively. The patients were grouped into the women <44 years old group and the women ≥ 44 years old group. Statistical analysis was performed using Student’s t-test and Fisher’s exact test as appropriate.
Results: An overall clinical pregnancy rate per retrieval was 11% (30/271). Of these, clinical miscarriage rate were 33% (10/30) and the overall delivery rate was 7.4% (20/271) per retrieval, respectively. The women ≥44 years old group had significantly higher cancellation rate (13% vs. 25%), lower number of retrieved oocytes (6.17±4.62 vs. 4.13 4.07), decreased number of 2PN (4.83±3.61 vs. 3.46±3.12), and reduced embryos for transfer (3.52± .72 vs. 2.81±1.83) than the women <44 years old group. We found significantly lower clinical pregnancy rate (13.0% vs. 2.1%) and live birth rate (9.0% vs. 0.0%) in the women ≥44 years old group than the women <44 years old group.
Conclusion: The present study has shown that IVF outcome is seriously impaired in the women ≥ 44 years old.
|
|
|
KEYWORD
|
|
|
Maternal age, IVF outcome, Delivery rate, Miscarriage rate
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
  
|